Independent academic research group · VIT-AP University

Sustainable and Intelligent Bioengineering Systems

Engineering next-generation bioprocesses and biochips through microfluidics, continuous processing, experimental innovation and computational intelligence.

Explore our research ↗About the group

RESEARCH · INNOVATION · TRANSLATION

Actual automated microfluidic mRNA manufacturing platform and laboratory equipment — Original experimental platform · Published bioprocess research

MOLECULAR PERSPECTIVES

Bioengineering across scales

From molecular interactions to microfluidic devices and intelligent process platforms, SIBES explores engineering approaches that connect biological understanding with practical technologies.

Conceptual molecular animation illustrating nucleic-acid interactions. This is a visual illustration, not experimental footage or a validated molecular mechanism.

OUR RESEARCH

Two research themes. One integrated vision.

Real fabricated microfluidic mixing device for integrated processing

THEME 01

Intelligent Bioprocess Engineering

Continuous bioprocessing, integrated purification, PAT, chemometrics, machine learning and model-informed control.

Explore further ↗

THEME 02

Smart Biochip Engineering

Microfluidic chip design, CFD simulation, microfabrication, sensing, automation and biological applications.

Explore further ↗

CURRENT WORK & FUTURE HORIZONS

Research in practice

Published experimental research provides a foundation for future intelligent platforms. We distinguish completed contributions from ideas and directions being explored.

PUBLISHED WORK

Published achievements

Automated mRNA platforms, oscillatory microfluidic reactors and computer-vision-controlled separation.

Explore further ↗

Original research vision: nucleic acid manufacturing integrated with PAT, chemometrics and digital-twin modelling

EMERGING RESEARCH

Future directions

AI-assisted nucleic-acid manufacturing, hybrid Digital Twins and integrated sensing and biochips.

Explore further ↗

About SIBES

Authentic experimental integrated bioprocessing platform

SIBES is an independent research group led by Dr. Vikas Sharma at VIT-AP University, bringing together biological sciences, engineering and computational approaches.

Our research explores integrated systems that are efficient, adaptable and resource-conscious, with applications in biomanufacturing, molecular diagnostics and sensing.

Our mission and approach ↗

RESEARCH OUTPUTS

Selected publications

SELECTED PUBLICATION

End-to-end mRNA synthesis and purification

Lab on a Chip · 2026

Explore further ↗

SELECTED PUBLICATION

Oscillatory microfluidic bioreactor

Chemical Engineering Journal · 2025

Explore further ↗

SELECTED PUBLICATION

Computer-vision-assisted separation

Bioresource Technology · 2024

Explore further ↗

Join or collaborate

Explore opportunities at SIBES

Prospective PhD students may apply through VITREE. Research opportunities depend on funding and project availability.

Opportunities ↗